Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer

study shows affect of changes in weight in adulthood. PLus confirms extra risk (3x) if patient is overweight and a reduction of risk if patient loses weight or maintains steady BMI. They found simular result between both the classical oestrogen driven type I and the more aggresive type II endometrial ca. Authors suggest weight loss changes inflammatory cytokines and hormones. Study used case-control, and retroespective questionnaire, thus bias from women 'estimating' weight over time, and also used the BMI scale which isnt that great a measure of fat/weight/lean body mass etc. Also all other studies used a differing definition of 'weight cycling' thus one cant not compare between studies with ease. overall, weight cycling in adulthood, which results is changes in fat distribution may increase risk of endo cancer (both types), the patient who doesnt cycle weight/bmi is still at a risk, but if patient drops BMI/or maintains simular BMI when she was 20year old have less risk C.M. Nagle, L. Marquart, C.J. Bain, S. O’Brien, P.H. Lahmann, M. Quinn, M.K. Oehler, A. Obermair, A.B. Spurdle, P.M. Webb. Australian National Endometrial Cancer Study Group, Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer, European Journal of Cancer, Volume 49, Issue 12, August 2013, Pages 2717-2726,